組織紹介

医学専攻　病態制御医学系：分子機能学・代謝機能学講座の概要

構成員の紹介

教授	松村　欣宏	Yoshihiro MATSUMURA
助教	小泉　幸央	Yukio KOIZUMI
助教	安　健博	Jianbo AN
技術職員	藤原　誠樹	Seiki FUJIWARA

　

教育と研究の概要

主な担当授業

主な学部の授業
　講義等：医系化学（1年次）
　　　　　基礎医学Ⅰ【生体物質の代謝Ⅰ】（1年次）
　　　　　基礎医学Ⅱ【生体物質の代謝Ⅱ】（1年次）
　　　　　基礎医学アドバンストコース【分子機能学・代謝機能学】（2年次）
　実習等：生体分子解析学実習（1年次）
主な大学院の授業
　講義等：基礎医学総論（修士）
　　　　　バイオテクノロジーの最前線（修士）
　　　　　再生医学（修士）
　　　　　生命科学研究概論（博士）
　　　　　臨床医学研究概論（博士）
　実習等：先端的細胞培養技術（修士）
　　　　　基礎医学技術実習「細胞培養技術の原理と実践テクニック」（博士）
　　　　　再生医学・実習（博士）

主な研究対象

1.生活習慣病におけるエピジェネティクス研究
2.がん悪性化に関する研究
3.天然物由来の生物活性物質に関する研究

医学専攻　病態制御医学系：分子機能学・代謝機能学講座の概要

博士研究員・大学院生・研究生を募集中です。お気軽にご連絡ください（TEL: 018-884-6074/6075、e-mail : seika1jimu@med.akita-u.ac.jp）。

主な発表論文

1.Takahashi H, Ito R, Matsumura Y, Sakai J. Environmental factor reversibly determines cellular identity through opposing Integrators that unify epigenetic and transcriptional pathways. Bioessays e2300084, 2023.
2.Kemuriyama K, An J, et al. Squamous cell carcinoma-derived G-CSF promotes tumor growth and metastasis in mice through neutrophil recruitment and tumor cell proliferation, associated with poor prognosis of the patients. Genes Cells 28(8), 573-584 2023.
3.Matsumura Y, Wei FY, Sakai J. Epitranscriptomics in metabolic disease. Nature Metabolism 5(3): 370-384, 2023.
4.An J, et al. Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression. Oncogene 41(50): 5319-5330, 2022.
5.Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, Nakazono J, Okamoto-Katsuyama M, Uchida A, Arai M, Jin H, Choi H, Tumenjargal M, Xie S, Zhang J, Sagae H, Zhao Y, Yamaguchi R, Nomura Y, Shimizu Y, Yamada K, Yasuda S, Kimura H, Tanaka T, Wada Y, Kodama T, Aburatani H, Zhu MS, Inagaki T, Osborne TF, Kawamura T, Ishihama Y, Matsumura Y, Sakai J. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nature Communications 13(1): 5715, 2022.
6.Fujita H, Motoyama S, An J, et al. Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer. Surgery 171(6): 1535-1542, 2022.
7.Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J. Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis. Nature Communications 12(1): 7045, 2021.
8.Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, et al. ACE2-like carboxypeptidase B38-CAP protects from SARS- CoV-2-induced lung injury. Nature Communications 12(1): 6791, 2021.
9.Nagaki Y, Motoyama S, Yamaguchi T, Hoshizaki M, Sato Y, Sato T, Koizumi Y, et al. m6A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis. Genes to Cells 25(8): 547-561, 2020.
10.An J, et al. MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages. Journal of Molecular and Cellular Cardiology 133: 26-35, 2019.
11.Koizumi Y, et al. Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. ChemBioChem 20(12): 1563-1568, 2019.
12.Fujiwara S, Hoshizaki M, Ichida Y, Lex D, Kuroda E, Ishii KJ, Magi S, Okada M, Takao H, Gandou M, Imai H, Hara R, Herzog H, Yoshimura A, Okamura H, Penninger JM, Slutsky AS, Uhlig S, Kuba K, Imai Y. Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol 4(2) 258-268, 2019.
13.Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J. Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch. Nature Communications 9(1): 1566, 2018.
14.Koizumi Y, et al. Involvement of RSK1 activation in malformin- enhanced cellular fibrinolytic activity. Scientific Reports 8(1): 5472, 2018.
15.An J, et al. MKL1 expressed in macrophages contributes to the development of murine colitis. Scientific Reports 7(1): 13650-13650, 2017.
16.Koizumi Y, et al. Structure-activity relationship of cyclic pentapeptide malformins as fibrinolysis enhancers. Bioorganic and Medicinal Chemistry Letters 26(21): 5267-5271, 2016.
17.Matsumura Y, Nakaki R, Inagaki T, Yoshida A, Kano Y, Kimura H, Tanaka T, Tsutsumi S, Nakao M, Doi T, Fukami K, Osborne TF, Kodama T, Aburatani H, Sakai J. H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation. Molecular Cell 60(4): 584-596, 2015
18.Zhou X, Koizumi Y, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T. Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice. Cancer Science 106(5): 635-641, 2015.
19.Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nature Commnications 6: 7052, 2015.