Division and Department

Department of Otorhinolaryngology-Head and Neck Surgery


Takechiyo YAMADA, MD, PhD

A Greeting from the Professor

We have specialized in otorhinolaryngology, including head and neck malignant tumor surgery requiring reconstruction by autologous transplantation, endoscopic nasal sinus surgery, hearing improvement surgery, skull base surgery, pharynx and voice function improvement surgery also using endoscopies every field. All head and neck surgeries can be performed. Regarding the treatment of head and neck tumors and cancer, we have achieved the highest level of results and are actively working to improve the treatment results of head and neck cancer. In the basic and clinical field of nasal allergy, which is one of the main themes of the department, we are conducting basic and clinical research and have achieved many achievements. In the field of neuro-otology, surgical treatment (including endolymphatic sac detachment and acoustic neuroma) has been performed for dizziness that is difficult to treat conservatively, with satisfactory results. Hearing improvement surgery for various ear diseases is performed, including cochlear implants and middle ear implants, and the hearing loss screening system in Akita Prefecture, including universities. In terms of research activities, of course, we are actively conducting clinical research on treatment methods and treatment results.

Staff

Chief Professor:
Takechiyo YAMADA, MD, PhD

Associate Professor:
Sinsuke SUZUKI, MD, PhD
Yohei Kawasaki, MD, PhD

Research Areas

  1. Fungal allergic inflammation in upper airway.
  2. Japanese Cedar Pollinosis and nasal allergy.
  3. Head & Neck cancer stem cells.
  4. Beiomarkers during chemoradiotherapy in head and neck cancer.
  5. Biomarker for Eosinophilic Chronic Rhinosinusitis.
  6. Facial nerve palsy.
  7. Eosinophil ETosis and Eosinophilic Granulomatosis With Polyangiitis.
  8. Innate lymphoid cells in allergic diseases.
  9. Newborn hearing screening.
  10. Gene mutation screening in Japanese hearing loss patients.
  11. Mast cell degranulation and IgE.
  12. Human inner ear endolymphatic sac function.

Contact Information

Associate Professor: Sinsuke SUZUKI, MD, PhD

Phone: +81-18-884-6171
Fax: +81-18-836-2622
E-mail: suzukis@med.akita-u.ac.jp

Most Recent Achievements

  1. Miyabe Y, Tomizawa H, Saito H, Yamada T, Shiina K, Koizumi K, Kawasaki Y, Suzuki S, Fukuchi M, Ueki S, Ebihara T, Yamada T. Quantification of Aspergillus fumigatus antigen Asp f 1 in airway tissue and allergic inflammation. Allergy. 2022 Oct;77(10):3154-3156. doi: 10.1111/all.15428.
  2. Kawasaki Y, Suzuki H, Suzuki S, Yamada T, Suzuki M, Ito A, Hatakeyama H, Miura M, Omori Y. GPNMB-Positive Cells in Head and Neck Squamous Cell Carcinoma-Their Roles in Cancer Stemness, Therapy Resistance, and Metastasis.
    Pathol Oncol Res. 2022 Aug 19;28:1610450. doi: 10.3389/pore.2022.1610450. eCollection 2022.PMID: 36061142 Free PMC article.
  3. Tomizawa H, Saito H, Toyoma S, Kawasaki Y, Yamada T. Investigation of Cry J1 and Cry J2 Concentrations in Japanese Cedar Pollen and Non-Pollen Seasons. Iran J Public Health. 2022 Mar;51(3):705-707. doi: 10.18502/ijph.v51i3.8952.PMID: 35865050 Free PMC article.
  4. Suzuki H, Kawasaki Y, Miura M, Hatakeyama H, Shina K, Suzuki S, Yamada T, Suzuki M, Ito A, Omori Y. Tumor Infiltrating Lymphocytes are Prognostic Factors and Can Be Markers of Sensitivity to Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma.Asian Pac J Cancer Prev. 2022 Apr 1;23(4):1271-1278. doi: 10.31557/APJCP.2022.23.4.1271.PMID: 35485685 Free PMC article.
  5. Suzuki S, Toyoma S, Abe T, Endo T, Kouga T, Kaswasaki Y, Yamada T. 18F-FDG-PET/CT can be used to predict distant metastasis in hypopharyngeal squamous cell carcinoma. J Otolaryngol Head Neck Surg. 2022 Apr 1;51(1):13. doi: 10.1186/s40463-022-00568-8.PMID: 35365214 Free PMC article.
  6. Suzuki S, Toyoma S, Kawasaki Y, Yamada T.Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma.PLoS One. 2022 Jan 28;17(1):e0262549. doi: 10.1371/journal.pone.0262549. eCollection 2022.PMID: 35089951 Free PMC article.
  7. Imoto Y, Ueki S, Kato Y, Yoshida K, Morikawa T, Kimura Y, Kidoguchi M, Tsutsumiuchi T, Koyama K, Adachi N, Ito Y, Ogi K, Sakashita M, Yamada T, Schleimer RP, Takabayashi T, Fujieda S. Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis. Front Pharmacol. 2022 Jan 3;12:793607. doi: 10.3389/fphar.2021.793607. eCollection 2021.PMID: 35046816 Free PMC article.
  8. Suzuki S, Toyoma S, Kawasaki Y, Koizumi K, Iikawa N, Shiina K, Endo T, Abe T, Kouga T, Yamada T. Clinical Outcomes of Cetuximab and Paclitaxel after Progression on Immune Checkpoint Inhibitors in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.Medicina (Kaunas). 2021 Oct 23;57(11):1151. doi: 10.3390/medicina57111151.PMID: 34833369 Free PMC article.
  9. Sato T, Ohta N, Tareishi Y, Yamada T. Taste and acoustic reflex after recovery from facial muscle paralysis in patients with facial nerve palsy.
    Acta Otolaryngol. 2021 Nov;141(11):1027-1032. doi:10.1080/00016489.2021.1992499. Epub 2021 Oct 27.PMID: 34704872
  10. Fukuchi M, Kamide Y, Ueki S, Miyabe Y, Konno Y, Oka N, Takeuchi H, Koyota S, Hirokawa M, Yamada T, Melo RCN, Weller PF, Taniguchi M. Eosinophil ETosis-Mediated Release of Galectin-10 in Eosinophilic Granulomatosis With Polyangiitis.Arthritis Rheumatol. 2021 Sep;73(9):1683-1693. doi: 10.1002/art.41727. Epub 2021 Aug 11.PMID: 33750029 Free PMC article.
  11. Imoto Y, Sakashita M, Hayama M, Nakamaru Y, Suzuki M, Miyabe Y, Yamada T, Saito H, Yonekura S, Kondo K, Higaki T, Kawashima K, Urashima M, Fujieda S.The clinical features of intractable allergic rhinitis based on a questionnaire administered to clinicians. Allergol Int. 2021 Jul;70(3):373-375. doi: 10.1016/j.alit.2020.12.003. Epub 2021 Feb 25.PMID: 33642145 Free article.
  12. Suzuki S, Toyoma S, Kawasaki Y, Nanjo H, Yamada T. CD147 promotes invasion and MMP-9 expression through MEK signaling and predicts poor prognosis in hypopharyngeal squamous cell carcinoma. Adv Clin Exp Med. 2021 Jan;30(1):41-48. doi: 10.17219/acem/128228.PMID: 33529506 Free article.
  13. Ebihara T, Tatematsu M, Fuchimukai A, Yamada T, Yamagata K, Takasuga S, Yamada T. Trained innate lymphoid cells in allergic diseases. Allergol Int. 2021 Apr;70(2):174-180. doi: 10.1016/j.alit.2020.11.007. Epub 2020 Dec 13.PMID: 33328130 Free article.
  14. Suzuki S, Yamada T. Efficacy of Arytenoidectomy after Suture Lateralisation Failure in Patients with Bilateral Vocal Cord Paralysis.Case Rep Otolaryngol. 2020 Nov 12;2020:8822164. doi: 10.1155/2020/8822164. eCollection 2020.PMID: 33274095 Free PMC article.
  15. How to detect eosinophil ETosis (EETosis) and extracellular traps.
    Fukuchi M, Miyabe Y, Furutani C, Saga T, Moritoki Y, Yamada T, Weller PF, Ueki S.Allergol Int. 2021 Jan;70(1):19-29. doi: 10.1016/j.alit.2020.10.002. Epub 2020 Nov 12.PMID: 33189567 Free PMC article.
  16. Kawasaki Y, Omori Y, Saito H, Suzuki S, Yamada T. The investigation of salvage endoscopic laryngopharyngeal surgery after chemoradiotherapy.Wideochir Inne Tech Maloinwazyjne. 2020 Sep;15(3):511-518. doi: 10.5114/wiitm.2020.94518. Epub 2020 Apr 20.PMID: 32904634 Free PMC article.
  17. Toyoma S, Suzuki S, Kawasaki Y, Yamada T. SDF-1/CXCR4 induces cell invasion through CD147 in squamous cell carcinoma of the hypopharynx. Oncol Lett. 2020 Aug;20(2):1817-1823. doi: 10.3892/ol.2020.11744. Epub 2020 Jun 17.PMID: 32724425 Free PMC article.
  18. Sato T, Nakazawa M, Takahashi S, Mizuno T, Ishikawa K, Yamada T. Outcomes of regional-based newborn hearing screening for 35,461 newborns for 5 years in Akita, Japan. Int J Pediatr Otorhinolaryngol. 2020 Apr;131:109870. doi: 10.1016/j.ijporl.2020.109870. Epub 2020 Jan 10.PMID: 31951982
  19. Efficacy of chemotherapy after progression with nivolumab in squamous cell carcinoma of the head and neck.
    Suzuki S, Toyoma S, Tomizawa H, Yamada T, Iikawa N, Shiina K, Saito H, Koizumi K, Kawasaki Y, Yamada T.Auris Nasus Larynx. 2020 Jun;47(3):485-488. doi: 10.1016/j.anl.2019.06.004. Epub 2019 Jun 25.PMID: 3124864
  20. Fukuchi M, Ueki S, Saito H, Miyabe Y, Konno Y, Omokawa A, Saga T, Moritoki Y, Takeda M, Yamada T, Hirokawa M. Comparison of CD16-negative selection vs. MACSxpress system for isolation of blood eosinophils. Allergol Int. 2019 Sep;68S:S11-S13. doi: 10.1016/j.alit.2019.04.005. Epub 2019 May 6.PMID: 31072804 Free article. No abstract available.
  21. Suzuki S, Toyoma S, Tsuji T, Kawasaki Y, Yamada T. CD147 mediates transforming growth factor-β1-induced epithelial-mesenchymal transition and cell invasion in squamous cell carcinoma of the tongue. Exp Ther Med. 2019 Apr;17(4):2855-2860. doi: 10.3892/etm.2019.7230. Epub 2019 Jan 31.PMID: 30906472 Free PMC article.
  22. Yamada T, Miyabe Y, Ueki S, Fujieda S, Tokunaga T, Sakashita M, Kato Y, Ninomiya T, Kawasaki Y, Suzuki S, Saito H. Eotaxin-3 as a Plasma Biomarker for Mucosal Eosinophil Infiltration in Chronic Rhinosinusitis. Front Immunol. 2019 Feb 4;10:74. doi: 10.3389/fimmu.2019.00074. eCollection 2019.PMID: 30778348 Free PMC article.
  23. Kawasaki Y, Omori Y, Saito H, Suzuki S, Matsuhashi T, Yamada T. An investigation on endoscopic laryngopharyngeal surgery and related outcomes. Wideochir Inne Tech Maloinwazyjne. 2018 Sep;13(3):394-400. doi: 10.5114/wiitm.2018.76956.
  24. Iikawa N, Yamamoto Y, Kawasaki Y, Nishijima-Matsunobu A, Suzuki M, Yamada T, Omori Y. Intrinsic Oncogenic Function of Intracellular Connexin26 Protein in Head and Neck Squamous Cell Carcinoma Cells. Int J Mol Sci. 2018 Jul 23;19(7):2134. doi: 10.3390/ijms19072134.PMID: 30041406 Free PMC article.
  25. Sato T, Nakazawa M, Takahashi S, Mizuno T, Sato A, Noguchi A, Sato M, Katagiri S, Yamada T. Leaflets and continual educational offerings led to increased coverage rate of newborn hearing screening in Akita.Auris Nasus Larynx. 2018 Aug;45(4):673-679. doi: 10.1016/j.anl.2017.11.014. Epub 2017 Nov 28.PMID: 29196108
  26. Kitano T, Miyagawa M, Nishio SY, Moteki H, Oda K, Ohyama K, Miyazaki H, Hidaka H, Nakamura KI, Murata T, Matsuoka R, Ohta Y, Nishiyama N, Kumakawa K, Furutate S, Iwasaki S, Yamada T, Ohta Y, Uehara N, Noguchi Y, Usami SI. POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss. PLoS One. 2017 May 17;12(5):e0177636. doi: 10.1371/journal.pone.0177636
  27. Ogi K, Takabayashi T, Yamada T, Sakashita M, Kanno M, Narita N, Fujieda S. Trimellitic anhydride induces low-grade mast cell degranulation without specific IgE.Toxicol Rep. 2016 Sep 7;3:701-707. doi: 10.1016/j.toxrep.2016.09.001. eCollection 2016.PMID: 28959595 Free PMC article.
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  28. Yamada T, Ogi K, Sakashita M, Kanno M, Kubo S, Ito Y, Imoto Y, Tokunaga T, Okamoto M, Narita N, Fujieda S. Toll-like receptor ligands induce cytokine and chemokine production in human inner ear endolymphatic sac fibroblasts. Auris Nasus Larynx. 2017 Aug;44(4):398-403. doi: 10.1016/j.anl.2016.10.007. Epub 2016 Nov 21.PMID: 27884591

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